Anybody can have a reaction to any medication. The way I look at it, if your dog never has a problem with Trifexis, then it may be fine.
However, if your dog has the least change in behavior, anything out of the ordinary, anything at all, then I would discontinue immediately.
These changes can include vomiting, diarrhea, laying around for a day or two, or just seeming a little “not right.” Some people and their dogs have great luck with the medication, some people don’t; The dogs who are not doing well with it should not continue simply because it’s wonderful not to have to put something sticky on the back of their dog’s neck. I do believe that there are dogs who have taken Trifexis and become ill and died. In fact, I have a little dog under my care now who is touch and go, due to Trifexis. But so far so good. Fortunately, because I practice a slightly different kind of veterinary medicine, I don’t just intuitively believe everything that comes from a drug company is safe. For my patients who have any questions about the safety of Trifexis in their dogs, I have no problem with a two second check in the office when you come to buy flea and heartworm medicine: I am more than happy to muscle test your dog and make sure Trifexis is safe. If not, I’ll be happy to recommend an alternative so you can keep your baby protected and keep your house free of fleas.
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Dr. Cathy isn't just a pet lover and veterinarian. She's a published author, sought after pet health expert for the media, and a passionate and practical voice for pet owners everywhere.
Now retired, Dr. Cathy is proud to have built a successful veterinary practice as one of the few veterinarians that offered both traditional veterinary care and alternative medicine options.
My Shitzu is on Trifexis and after I gave it to her this last time, on the 27th of Sept., I’ve noticed she is lethargic, not eating well, and seems less coordinated. I am praying she will be ok. Is there anything safe I can do for her besides , obviously, not giving it to her again, and what are the safest alternatives? I live in the Houston area just 18 miles from the coast. The mosquitoes here have been a nightmare this year.
There are several other combination flea and heartworm products. Because they use completely different chemicals, any one of them would be a good switch. However, I’m more concerned about your little one’s continued lethargy. You can help your best by knowing what’s going on with her. I recommend you take her to your veterinarian as soon as possible for blood work. I am currently treating a little dog whose kidneys have shut down due to a Trifexis reaction. That’s the last thing you want for your baby! So, you’re absolutely right, finding another medication is in your best interest in the long run, but in the short run it’s probably a good idea to find out exactly what’s going on so you can get to the long run.